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Insulin resistance is common in patients with metabolic disorders and is found in the vast majority of those with multiple metabolic disorders. The researchers found insulin resistance in the following percentage of patients:

66% in subjects with impaired glucose tolerance,
84% in those with non-insulin dependent diabetes mellitus (NIDDM),
54% in participants with hypercholesterolemia,
84% in those with hyper triglyceridemia,
88% in subjects with low high-density lipoprotein (HDL) cholesterol levels,
63% in participants with hyperuricemia and
58% in those with hypertension.

In individuals with combined metabolic disorders, nearly all demonstrated insulin resistance, the researchers say. In particular, hypertriglyceridemia and low HDL cholesterol almost never occurred as isolated disorders, and were nearly always associated with insulin resistance.

On the other hand, insulin resistance was not significantly more common in patients with isolated hypercholesterolemia, hyperuricemia, or hypertension than in the study population as a whole, in which the prevalence was approximately 45%. Nearly 10% of subjects demonstrated insulin resistance in the absence of any metabolic disorder.

Diabetes October, 1998;47:1643-1649.

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